Treatment Guidelines - Issue 138 | The Medical Letter Inc.

Treatment Guidelines from The Medical Letter

FROM
ISSUE

138

February 1, 2014

View Complete Issue Table of Contents 2019

Issue 138

Drugs for HIV Infection

Subscribers: Log in to read full issue. Not a subscriber? Subscribe or purchase issue.

Drugs for HIV Infection

February 1, 2014 (Issue: 138)

Antiretroviral therapy is recommended for all HIV-infected patients, both to reduce the risk of disease progression and to prevent transmission of the virus to others. Various guidelines for treatment of HIV infection are available.

Show References Hide References

1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at www.aidsinfo.nih.gov. Accessed January 15, 2014.

2. MA Thompson et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA 2012; 308:387.

3. MS Cohen et al. Prevention of HIV-1 infection with early retroviral therapy. N Engl J Med 2011; 365:493.

4. JA Aberg et al. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2014; 58:e1.

5. PE Sax et al. Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results. J Infect Dis 2011; 204:1191.

6. KY Smith et al. Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS 2009; 23:1547.

7. SL Walmsley et al. Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection. N Engl J Med 2013; 369:1807.

8. ES Daar et al. Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1. Ann Intern Med 2011; 154:445.

9. Rilpivirine (Edurant) – a new drug for HIV infection. Med Lett Drugs Ther 2011;53:67.

10. CJ Cohen et al. Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial. Lancet 2011; 378:229.

11. JM Molina et al. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet 2011; 378:238.

12. P Tebas et al. SPIRIT study: switching boosted PI to rilpivirine in-combination with Truvada as a single-tablet regimen week 24 results. 14th International Workshop on Co-morbidities and Adverse Drug Reaction in HIV.; Washington DC, July 20 2012. Available at: http://www.natap.org.

13. R Schrijvers et al. Rilpivirine: a step forward in tailored HIV treatment. Lancet 2011; 378:201.

14. E Poveda et al. Phenotypic impact of resistance mutations on etravirine susceptibility in HIV patients with prior failure to nonnucleoside analogues. AIDS 2008; 22:2395.

15. JM Molina et al. Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study. J Acquir Immune Defic Syndr 2010; 53:323.

16. Panel on treatment of HIV-infected pregnant women and prevention of perinatal transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Available at www.aidsinfo.nih.gov. Accessed January 5, 2014.

17. AM Mills et al. Once-daily darunavir/ritonavir vs. lopinavir/ritonavir in treatment-naive, HIV-1-infected patients: 96-week analysis: AIDS 2009; 23:1679.

18. D Bánhegyi et al. Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN. Curr HIV Res 2012; 10:171.

19. J Eron Jr et al. The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial. Lancet 2006; 368:476.

20. S Walmsley et al. Gemini: a noninferiority study of saquinavir/ritonavir versus lopinavir/ritonavir as initial HIV-1 therapy in adults. J Acquir Immune Defic Syndr 2009; 50:367.

21. M Markowitz et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr 2007; 46:125.

22. JL Lennox et al. STARTMRK Investigators. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009; 374:796.

23. JJ Eron et al. Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials. Lancet 2010; 375:396.

24. E Vispo et al. simplificationfrom protease inhibitors to once- or twice-daily raltegravir: the ODIS Trial. HIV Clin Trials 2010; 11:197.

25. E Martínez et al. Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL study. AIDS 2010; 24:1697.

26. A 4 drug combination (Stribild) for HIV. Med Lett Drugs Ther 2012; 54:95.

27. PE Sax et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379:2439.

28. E DeJesus et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet 2012; 379:2429.

29. Dolutegravir (Tivicay) for HIV. Med Lett Drugs Ther 2013; 55:77.

30. F Raffi et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet 2013; 381:735.

31. J Feinberg et al. Once-daily dolutegravir (DTG) is superior to darunavir/ritonavir (DRV/r) in antiretroviral naive adults: 48 week results from FLAMINGO. Presented at 53rd Interscience Con ference on Antimicrobial Agents and Chemotherapy. Denver, CO; September 10-13, 2013. Available at http://www.icaaconline.com. Accessed January 5, 2014.

32. JJ Eron et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis 2013; 207:740.

33. M Westby et al. Emergence of CXCR4-using human immunoDeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 2006; 80:4909.

34. AM Cotter et al. Is antiretroviral therapy during pregnancy associated with an increased risk of preterm delivery, low birth weight, or stillbirth? J Infect Dis 2006; 193:1195.

35. DH Watts et al. Combination antiretroviral use and preterm birth. J Infect Dis 2013; 207:612.

36. JY Chen et al. Highly active antiretroviral therapy and adverse birth outcomes among HIV-1 infected women in Botswana. J Infect Dis 2012; 206:1695.

37. In brief: Truvada for HIV prevention. Med Lett Drugs Ther 2012; 54:63.

38. RM Grant et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363:2587.

39. JM Baeten et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012; 367:399.

40. Centers for Disease Control. Update to interim guidance for preexposure prophylaxis (PrEP) for the prevention of HIV infection: PrEP for injecting drug users. MMWR Morb Mortal Wkly Rep 2013; 62:463.

41. DT Kuhar et al. Updated US Public Health Service guidelines for the management of occupational exposures to human immunoDeficiency virus and recommendations for postexposure prophylaxis. Infect Control Hosp Epidemiol 2013; 34:875.

42. DK Smith et al. Antiretroviral postexposure prophylaxis after sexual, injection drug-use or other nonoccupational exposure to HIV in the United States. Recommendations from the U.S. Department of Health and Human Services. MMWR Recomm Rep 2005; 54 (RR-2):1.

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.