The FDA has approved Cobenfy (BMS), an oral fixed-dose combination of the muscarinic agonist xanomeline and the peripheral muscarinic antagonist trospium chloride, for treatment of schizophrenia in adults. It is the first antipsychotic drug to be approved in the US for treatment of schizophrenia that does not block dopamine receptors. This is the first approval for xanomeline; trospium has been available for many years for treatment of overactive bladder.
STANDARD TREATMENT — Drugs that target dopamine receptors are the standard of care for treatment of schizophrenia; second-generation...
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RELEASE
Femlyv (Millicent), an orally-disintegrating tablet containing ethinyl estradiol and norethindrone acetate, has been approved by the FDA for prevention of pregnancy in females with a body mass index (BMI) ≤35 kg/m2. It is the first hormonal contraceptive to become available in an orally-disintegrating tablet formulation. Traditional oral and chewable tablets containing ethinyl estradiol and norethindrone acetate in a wide range of doses, including those found in Femlyv, have been available in the US for years.
CHOICE OF CONTRACEPTIVES — Intrauterine devices (IUDs) and the etonogestrel implant (Nexplanon) are the most effective reversible contraceptive methods, but they require an office visit for placement and removal. Combination and progestin-only hormonal contraceptives (oral tablets, transdermal patches, …