The Medical Letter on Drugs and Therapeutics
FROM
ISSUE1512
ISSUE1512
January 16, 2017
Drugs for Type 2 Diabetes
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Drugs for Type 2 Diabetes
January 16, 2017 (Issue: 1512)
The goal of drug therapy for type 2 diabetes is
to achieve and maintain a near-normal glycated
hemoglobin (A1C) concentration without inducing
hypoglycemia; the target is generally an A1C of
≤7%. Treating to this target has been shown...more
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- Exenatide (Byetta) for type 2 diabetes. Med Lett Drugs Ther 2005; 47:45.
- Extended-release exenatide (Bydureon) for type 2 diabetes. Med Lett Drugs Ther 2012; 54:21.
- SP Marso et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016; 375:311.
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- Lixisenatide for type 2 diabetes. Med Lett Drugs Ther 2017; 59:19.
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- Alogliptin (Nesina) for type 2 diabetes. Med Lett Drugs Ther 2013; 55:41.
- Linagliptin (Tradjenta) – a new DPP-4 inhibitor for type 2 diabetes. Med Lett Drugs Ther 2011; 53:49.
- Saxagliptin (Onglyza) for type 2 diabetes. Med Lett Drugs Ther 2009; 51:85.
- Sitagliptin (Januvia) for type 2 diabetes. Med Lett Drugs Ther 2007; 49:1.
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- Canagliflozin (Invokana) for type 2 diabetes. Med Lett Drugs Ther 2013; 55:37.
- Dapagliflozin (Farxiga) for type 2 diabetes. Med Lett Drugs Ther 2014; 56:13.
- Empagliflozin (Jardiance) for diabetes. Med Lett Drugs Ther 2014; 56:99.
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- In brief: Rosiglitazone (Avandia) unbound. Med Lett Drugs Ther 2014; 56:12.
- Pramlintide (Symlin) for diabetes. Med Lett Drugs Ther 2005; 47:43.
- In brief: a new indication for colesevelam (Welchol). Med Lett Drugs Ther 2008; 50:33.
- Bromocriptine (Cycloset) for type 2 diabetes. Med Lett Drugs Ther 2010; 52:97.
- JM Gaziano et al. Effect of bromocriptine-QR (a quick-release formulation of bromocriptine mesylate) on major adverse cardiovascular events in type 2 diabetes subjects. J Am Heart Assoc 2012; 1:e002279.
- Rapid-acting insulin analogues. Med Lett Drugs Ther 2009; 51:98.
- An inhaled insulin (Afrezza). Med Lett Drugs Ther 2015; 57:34.
- Another insulin glargine (Basaglar) for diabetes. Med Lett Drugs Ther 2017; 59:3.
- MC Riddle et al. One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in people with type 2 diabetes using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extension. Diabetes Obes Metab 2015; 17:835.
- Concentrate insulin glargine (Toujeo) for diabetes. Med Lett Drugs Ther 2015; 57:69.
- Insulin detemir (Levemir), a new long-acting insulin. Med Lett Drugs Ther 2006; 48:54.
- P Hollander et al. Insulin degludec improves long-term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal-bolus insulin therapy. Diabetes Obes Metab 2015; 17:202.
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- Insulin degludec (Tresiba) – a new long-acting insulin for diabetes. Med Lett Drugs Ther 2015; 57:163.
- SP Marso et al. Design of DEVOTE (trial comparing cardiovascular safety of insulin degludec vs insulin glargine in patients with type 2 diabetes at high risk of cardiovascular events) - DEVOTE 1. Am Heart J 2016; 179:175.
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- KC Ferdinand et al. Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events. Cardiovasc Diabetol 2016; 15:38.
- C Sorli et al. Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational multicentre phase 3a trial. Lancet Diabetes Endocrinol 2017; 5:251.
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- AJ Ahmann et al. Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56-week, open-label, randomized clinical trial. Diabetes Care 2018; 41:258.
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- RE Pratley et al. Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomized, open-label, phase 3b trial. Lancet Diabetes Endocrinol 2018 Jan 31 (epub).
- SP Marso et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 2016; 375:1834.
- MA Bethel et al. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol 2017; 6:105.
- B Neal et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 2017; 377:644.
- Ertugliflozin for type 2 diabetes. Med Lett Drugs Ther 2018; 60:70.
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Title: Drugs for Type 2 Diabetes
Article code: 1512a
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